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Final Program

Program: Monday, May 13, 2024

09.00 h

Bus to Thesinge departs from the main entrance, University Medical Center (UMCG), Hanzeplein, Groningen, The Netherlands

09.30 – 10.00 h

Registration with coffee/tea

Poster mounting (see last pages for poster overview)

10.00 – 10.05 h

“Welcome to Thesinge” by Henny van der Mei


Chair: Henny van der Mei

10.05 – 10.35 h

Opening Lecture: Henk Busscher, UMCG, Groningen, The Netherlands

Beyond surface modification strategies to control infections

associated with implanted biomaterials and devices - addressing the opportunities offered by nanotechnology

10.35 – 10.55 h

Colin McCoy, Queen's University Belfast, Belfast, United Kingdom

Synergy between antimicrobial and anti-adherent mechanisms to reduce biofilm formation

10.55 – 11.15 h

Filipe J. Mergulhão, University of Porto, Porto, Portugal

Using carbon nanotube-based surfaces to inhibit single- and dual-species biofilms of uropathogenic bacteria 

11.15 – 11.30 h

Shun Duan, Beijing University of Chemical Technology, Beijing, China

Multi-scale antibacterial materials

11.30 – 11.45 h

Fintan Moriarty, AO Foundation, Davos, Switzerland

Targeted poly (D-amino acids) nanoparticles loaded with sitafloxacin for staphylococcal biofilm eradication

11.45 – 12.00 h

Patricia Nadworny, Innovotech, Edmonton, Canada

Unique antibiofilm nanostructured silver compound for use in gel and polymer coating

12.00 – 12.15 h

Karina de Almeida Lins, University of Nottingham, Nottingham, United Kingdom

Development of neonatal medical devices with reduced infection risk using biofilm inhibiting polymers

12.15 13.00 h


13.00 14.00 h

Posters, presenters be present at your poster


Chair: Terri Camesano

14.00 – 14.45 h

Keynote Lecture: Kees Poelstra, the Robotic Spine Institute of Las Vegas, Allegiant Institute, Nevada, USA

The clinical problem of (biomaterials-associated) infection 

14.45  – 15.00 h

Sarah Nick, University of Washington, Seattle, USA

Nanoscale layer-by-layer functionalized gauze for synthetic anti-biofilm peptide release at wound sites

15.00 – 15.15 h

Miryana Hemadi, Université Paris Cité, Paris, France

Applications of nanohybrid materials for eliminating bacterial biofilms

15.15 – 15.30 h

Adéla Melcrová, UMCG, Groningen, The Netherlands

Stiffening activity of peptidomimetic AMC-109 as a way towards lower adhesion

15.30 – 15.45 h

Matthew Wylie, Queen's University Belfast, Belfast, United Kingdom

Small molecule antibacterials possessing anti-virulence properties to disarm P. mirabilis and disrupt crystalline biofilm formation

15.45 16.15 h

Coffee, Tea break


Chair: Henk Busscher

16.15 – 17.00 h

Key Note Lecture: Linqi Shi, Nankai University, Tianjin, China

Responsive nano antibiotics for controlling bacterial biofilm infection

17.00 – 17.20 h

Roger Bayston, University of Nottingham, Nottingham, United, Kingdom

The importance of Small Colony Variants (SCV) as major components of the established biofilm

17.20 – 17.35 h

Leanne Fisher, University of Nottingham, Nottingham, United Kingdom

Polymer-based coating on a chest drain

17.35 h

Group photo

NOTE: if you have any objection to be in the group photo and have the photo distributed among the participants, please do not join and let the organizers know.


Social Program

Hosted by the Thesinge Village Community

18.00 – 19.00 h

Village Tour

19.00 – 21.00 h

BBQ dinner

  21.15 h

Return bus to Groningen leaves Dorphuis Trefpunt


Programma: Tuesday, May 14, 2024

08.15 h

Bus to Thesinge departs from the main entrance of University Medical Center (UMCG), Hanzeplein, Groningen, The Netherlands


Chair: Toby Jenkinson

09.00 – 09.45 h

Keynote Lecture: Anna Salvati, RuG, Groningen

Understanding how nanomedicine can help against biofilms and infections

09.45 – 10.00 h

Mihyun Lee, Empa, St. Gallen, Switzerland

The impact of host polymers on the growth of P. aeruginosa

10.00 – 10.15 h

Matt Price, University of Nottingham, Nottingham, United Kingdom

Designing a ChemoTopoChip to identify synergistic biofilm resistant combinations

10.15 – 10.30 h

Li Peng, Northwestern Polytechnical University, Xi’an, China

Antimicrobial biomaterials and wearable optoelectronic devices

10.30 – 11.00 h

Coffee/Tea break/poster discussion


Chair: James Bryers

11.00 – 11.45 h

Keynote Lecture: Bas Zaat, AUMC, Amsterdam, The Netherlands

Are biomaterials-associated infections any different from other types of infection?

11.45 – 12.00 h

Toby Jenkins, University of Bath, Bath, United Kingdom

Measurement of early-stage biofilms via virulence factors in wounds

12.00 - 12.15 h

Jelmer Sjollema, UMCG, Groningen, The Netherlands

The effect of micrococcal nuclease secretion by Staphylococcus aureus in biomaterial associated infections

12.15 – 12.30 h

Laurent Royon, Université Paris Cité, Paris, France

Destruction of biofilms by photothermia

12.30 - 12.45 h

Fong-Fu Hsu, Washington school of Medicin, St. Louis, USA

Characterization of complex lipid structures isolated from biofilm of Mycobacteria

12.45 – 14.00 h

Hosted Lunch and poster discussion


Chair: Fintan Moriarty

14.00 – 14.15 h

Alexander Dulebo, Bruker, Berlin, Germany

Multiparametric investigation of bacterial surface structure with correlative atomic force microscopy

14.15 – 14.30 h

Terri Camesano, Worcester Polytech Institute, Worcester, USA

Mechanisms of antimicrobial peptide and antibiotic interactions on membrane permeabilization and deactivation of Escherichia coli

14.30 – 14.45 h

Raphaelle Youf, University Hospital Regensburg, Regensburg, Germany

K-wires with biofilm in Galleria mellonella larvae treated with rifampicin      

14.45 – 15.00 h

Vincent Hickl, Empa, St. Gallen, Switzerland

Single-cell live imaging of bacterial infections at 3D surfaces

15.00 – 15.15 h

Mohamed E. Labib, Novaflux, Princeton, USA

Physical removal of dental biofilms using a novel toothpaste

15.15 – 15.30 h

Da-Yuan Wang, Nankai University, Tianjin, China

The mechanism of nanocarriers penetration in bacterial biofilms

15.30 – 16.00 h

Coffee/Tea break and wrapping up posters


Chair: David Grainger

16.00 – 17.00 h

Off-the-floor presentations and general discussion

Heated by David Grainger

17.00 h

Closure by David Grainger

17.30 h

Return bus to Groningen leaves Dorpshuis Trefpunt



Poster size: Portrait A0 (width 84.1 x height 118.9 cm)


Olga Lungin, Kyiv National University of Technologies and Design, Kyiv, Ukraine

Controversive effects of metal-based nanoparticles use for planktonic growth and biofilm eradication in wounds


Siran Wang, UMCG, Groningen, The Netherlands

Antibacterial/anti-inflammatory synergistic nanomedicine for acute peritonitis


Veridianna Camilo Pattini, UMCG, Groningen, The Netherlands

Curcuminoid is a multifunctional coating with anti-adhesion and anti-biofilm formation of Candida albicans


Paria Mojarrad, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Combination therapy against drug resistance biomimetic multispecies biofilms


Rita Teixeira-Santos, University of Porto, Porto, Portugal

Nitric acid-functionalized carbon nanotube-based surfaces to mitigate biofilm development on implantable medical devices


Yuanlong Cao, UMCG, Groningen, The Netherlands

An antimicrobial peptide and chemotherapeutic dual-loaded in liposomes for treatment of bacterial-infected tumors


Ana Sofia Pinho, Institute for Research and Innovation in Health, Porto, Portugal

An in vitro biofilm model to explore nanostructured lipid carriers as a novel strategy against H. pylori biofilm


Xu Yin, UMCG, Groningen, The Netherlands

Poly(β-amino esters)-based micelles for delivering contrast agents to detect biofilm infections


Pamela Moussa, Wetsus, Leeuwarden, The Netherlands

Beyond chlorine: alternative sustainable compounds to remove biofilms from drinking water environments


Teresa Vinuesa, University of Barcelona, Barcelona, Spain

Approaches to oral biofilm modelling for evaluation of antimicrobial products


Guimei Jiang, UMCG, Groningen, The Netherlands

How to deal with antibiotic-resistance


Robyn Deeks, University of Bath, Bath, United Kingdom

Development of a probiotic wound dressin


Tianrong Yu, UMCG, Groningen, The Netherlands

Application of Pt-nanoparticle loaded Bi2Se3 nanosheets to in vivo infected wounds and ex vivo human oral biofilms


Nikitha Vavilthota, AUMC, Amsterdam, The Netherlands

Peptide-hydrogel based wound dressings


Olena Moshynets, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Nano-microstructured metal surfaces demonstrated alteration in biofilm architecture and reduction in biofilm formation


Qiaolan Shi, UMCG, Groningen, The Netherlands

Catalytic and anti-biofilm activities of Pt single-atoms and differently-sized Pt nanoparticles supported by manganese-oxide nanosheets


Deeksha Rajkumar, AUMC, Amsterdam, The Netherlands

Novel bioactive glass S53P4 cream to prevent orthopedic implant-associated infection


Lu Yuan, UMCG, Groningen, The Netherlands

The influence of oxygen levels on macrophages’ phagocytosis


Tianqi Zhang, Karolinska Institutet, Solna, Sweden

Visualization and quantification of uropathogenic Escherichia coli biofilm development with optotracing technology


Cong Li, UMCG, Groningen, The Netherlands

Inheritance of chitosan-like properties by hydrothermally-derived carbon quantum dots


Laure van Hofwegen, AUMC, Amsterdam, The Netherlands

The fungicidal activity of graphene quantum dots against Candida species


Magnus Schou- Jørgensen, Aarhus University, Aarhus, Denmark

Prodrugs of mitomycin C using the antibiotic vancomycin as a targeting agents


Yaran Wang, UMCG, Groningen, The Netherlands

Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections in vitro and in vivo


Guang Yang, UMCG, Groningen, The Netherlands

Metabolic incorporation of ROS-generating cascade-reaction containers in bacterial cell walls for infectioncontrol


Fan Wu, UMCG, Groningen, The Netherlands

Cu anchored on carbon nitride as a bifunctional glucose oxidase and peroxidase nanozyme for antibacterial therapy


Gizem Babucccu, AUMC, Amsterdam, The Netherlands

Microbial interactions and treatment strategies in Staphylococcus aureusCandida albicans dual-species biofil


Cédric Vranckx, Université Catholique de Louvain, Louvain-la-Neuve, Belgium

Antibiotics or antimicrobial coatings? Evaluating combined treatment approaches for the removal of staphylococcal biofilm-related infections


Renfei Wu, UMCG, Groningen, The Netherlands

Bacterial killing and the dimensions of bacterial death


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The 9th Thesinge biofilm meeting on biomaterial-associated infections
May 13-14, 2024

in biomaterial-associated infection?

May 13-14, 2024

Thesinge, a picturesque rural village, 9 km north of the city of Groningen, The Netherlands


Hosted by the rural village community of Thesinge, the Thesinge biofilm meetings have provided a unique scientific forum for a small, select group of maximally 100 people active in the field, collected for two days "away from it all" to focus formally and informally on infectious biofilms, with emphasis on biofilms on biomaterials implants, medical devices and oral surfaces.

Thesinge biofilm meetings seek to provide open, provocative discourse to stimulate thinking and creative approaches in a friendly, family-style atmosphere. There are no proceedings, only a program book, and active exchange.

What's it about

The mere expression “biomaterial-associated infection” and the involvement of surface-adhering microorganisms (“the biofilm”) have made biomaterial surface modifications that discourage bacterial adhesion a most logical prophylactic approach. Yet, biomaterial surface modification has never become a clinically embraced solution. Reasons and excuses for why so few surface modifications have clinical applications are ample. The recalcitrance of the biofilm-mode of bacterial growth to antimicrobial penetration and intrinsic antimicrobial-resistance amongst causative pathogens have stymied effective therapeutic approaches.

Often biomaterial-associated infections are considered unique because of the involvement of a biomaterial surface, but is this really so? Most human infections are due to microorganisms in a biofilm-mode of growth, if only adhering to each other’s surface. Are biomaterial-associated infections truly distinct from other types of microbial infections? Should not we re-locate the finish line in the race for the surface in a direction away from surface modification, perhaps towards nanotechnological solutions applicable to different infection types? Nano-antimicrobials and nanocarriers loaded with conventional antibiotics are claimed in preclinical models to circulate freely through the blood, respond to the biofilm’s local micro-environment to penetrate and accumulate deeply within a biofilm, generate ROS under synergistic action with existing antibiotics to kill also antibiotic-resistant pathogens without inducing further antimicrobial-resistance, and boost the frustrated immune system around a biomaterial implant. Problem solved?


All participants are asked to contribute intellectual and other creative input to inspiring new information, new ideas, new approaches and new expertise to participants, but to always address the meeting’s central focus question in their final slide.

Symposium format:

Informal single-track sessions with participation limited to 100 people. Emphasis is on exchange and discussion, and the program is set up such that we try to allow as many participants as possible to give a presentation. The floor is open!

Keynote Speakers:

  • Linqi Shi

    Nankai University, Tianjin, China

    “Stimuli-responsive antimicrobial (carrying) micelles”

  • Kees Poelstra

    The Robotic Spine Institute of Las Vegas/Nevada Spine Clinic/Allegiant Institute.

    7140 Smoke Ranch Rd., Las Vegas, NV 89128. 

    “The clinical problem of (biomaterials-associated) infection”

  • Bas Zaat

    Amsterdam University Medical Center, The Netherlands

    “Are biomaterials-associated infections any different from other types of infection?”

  • Anna Salvati

    University of Groningen, Groningen, The Netherlands

    “A view on the prospects of stimuli-responsive drug-carriers”

We distinguish three different types of scheduled presentations and off-the-floor presentations by participants:

Selected lectures:

Participants selected by the organizers invited to give 30-min lectures.

Mini Lectures:

Participants selected by the organizers invited to give 15-min lectures


Opportunities for 5-min “hot topic” or “point-counterpoint” off-the-floor-addresses at the close of Tuesday under the stimulating leadership of David Grainger.

In order to participate, please register at .
For information and any questions, send an email to: This email address is being protected from spambots. You need JavaScript enabled to view it..

**Applicants are accepted as symposium participants on a “first come, first served” basis. Please note that the registration fee, including daily transportation to and from Groningen, coffee breaks, lunch as well as the symposium BBQ, amounts to 390 euro.

Admission will be definitely closed after 100 in-person participants are registered.

Those attending should plan to arrive in Groningen, NL (about a 2.5-hour train ride from Amsterdam-Schiphol airport), by Monday morning, May 13, 9.00 h at the latest for meeting-arranged transport to Thesinge, outside of the city of Groningen.

The Thesinge meeting ends Tuesday afternoon, May 14 at 17.30 h with pre-arranged transportation back to Groningen at 17.30 h.

Housing possibilities, and further registration and on-site meeting schedule details will be provided in future correspondence to attendees.

On behalf of the 9th Thesinge organizing committee and the citizens of Thesinge:

  • Henny van der Mei

  • Henk Busscher

  • David Grainger

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